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Fatigue is a form of generalized pain whose function is to signal the need for rest and recuperation. But chronic fatigue is usually a misleading signal that does more harm than good, and needs treatment. Since it is a type of pain, analgesics/ pain-killers may be an effective treatment of fatigue. Fatigue is an emotion - and an emotion is a body state as perceived by the brain. For example, anxiety is the brain’s perception of the body’s physical state of arousal and preparedness for action (hair on end, thumping heart etc). Similarly, fatigue is the brain’s perception of a state of physical exhaustion of the body induced by excessive activity. The brain interprets these body signals of fatigue as indicating a need to stop activity. Fatigue is therefore an emotion that signals the need for rest, for physical recuperation. So fatigue can be considered a negative-feedback signal, which limits the amount of physical activity. The more prolonged and vigorous the activity...